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Hisashi Yamanaka Selected Research

Methotrexate (Mexate)

4/2022Risk of herpes zoster in patients with rheumatoid arthritis in the biologics era from 2011 to 2015 and its association with methotrexate, biologics, and corticosteroids.
4/2022Influence of Concomitant Methotrexate use on the Clinical Effectiveness, Retention, and Safety of Abatacept in Biologic-Naïve Patients with Rheumatoid Arthritis: Post-hoc Subgroup Analysis of ORIGAMI Study.
2/2022Factors associated with frailty in Japanese patients with rheumatoid arthritis: results from the Institute of Rheumatology Rheumatoid Arthritis cohort study.
1/2021Efficacy and Safety of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Study.
5/2020Effectiveness, safety, and methotrexate dose-tapering pattern over two years of treatment with adalimumab and ≥12 mg/week methotrexate for early rheumatoid arthritis: Results of the HAWK postmarketing surveillance study in Japan.
3/2020Factors associated with successful discontinuation of certolizumab pegol in early rheumatoid arthritis.
1/2020Management of End-stage Renal Disease Associated with Systemic Rheumatic Diseases.
9/2019Efficacy and safety of tofacitinib in Japanese patients with rheumatoid arthritis by background methotrexate dose: A post hoc analysis of clinical trial data.
7/2019Effectiveness and safety of initiating adalimumab plus ≥12 mg/week methotrexate with adjustable dosing in biologic-naïve patients with early rheumatoid arthritis: HAWK study postmarketing surveillance in Japan.
1/2019Efficacy of denosumab with regard to bone destruction in prognostic subgroups of Japanese rheumatoid arthritis patients from the phase II DRIVE study.
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Hisashi Yamanaka Research Topics

Disease

199Rheumatoid Arthritis
08/2022 - 04/2002
21Gout
12/2021 - 08/2005
17Infections
02/2022 - 01/2005
15Hyperuricemia
12/2021 - 01/2003
15Interstitial Lung Diseases (Interstitial Lung Disease)
07/2019 - 07/2010
15Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2017 - 11/2003
14Dermatomyositis (Dermatopolymyositis)
07/2019 - 07/2010
11Pain (Aches)
09/2020 - 12/2005
8Drug-Related Side Effects and Adverse Reactions
05/2020 - 12/2002
7Arthritis (Polyarthritis)
01/2018 - 01/2010
6Systemic Scleroderma (Systemic Sclerosis)
01/2019 - 05/2011
5Herpes Zoster
04/2022 - 10/2014
5Gouty Arthritis
01/2021 - 09/2002
5Osteoporosis
01/2021 - 01/2009
5Neoplasms (Cancer)
10/2020 - 09/2012
5Melanoma (Melanoma, Malignant)
01/2018 - 09/2012
5Myositis (Idiopathic Inflammatory Myopathies)
01/2018 - 07/2012
5Inflammation (Inflammations)
08/2017 - 01/2007
5Autoimmune Diseases (Autoimmune Disease)
08/2017 - 07/2008
4Lupus Nephritis
01/2020 - 08/2011
4Fibrosis (Cirrhosis)
01/2019 - 09/2010
4Polymyositis
01/2018 - 10/2010
4Rheumatic Diseases (Rheumatism)
11/2017 - 01/2007
3Vitamin D Deficiency
01/2021 - 07/2013
3Psoriatic Arthritis
06/2019 - 10/2012
3Genetic Predisposition to Disease (Genetic Predisposition)
01/2019 - 01/2015
3Synovitis
01/2018 - 01/2009
3Pneumonia (Pneumonitis)
10/2011 - 06/2010
2Juvenile Arthritis (Juvenile Idiopathic Arthritis)
09/2020 - 07/2014

Drug/Important Bio-Agent (IBA)

46Methotrexate (Mexate)FDA LinkGeneric
04/2022 - 04/2002
30Biological ProductsIBA
08/2022 - 01/2007
28Antirheumatic Agents (DMARD)IBA
08/2022 - 12/2002
23Uric Acid (Urate)IBA
12/2021 - 09/2002
19Adalimumab (Humira)FDA Link
05/2020 - 04/2011
17Pharmaceutical PreparationsIBA
03/2022 - 12/2002
16Adrenal Cortex Hormones (Corticosteroids)IBA
04/2022 - 01/2007
16tocilizumab (atlizumab)FDA Link
05/2020 - 04/2011
14Etanercept (Enbrel)FDA Link
03/2020 - 01/2006
13Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2021 - 01/2006
13Monoclonal AntibodiesIBA
07/2021 - 01/2008
12Proteins (Proteins, Gene)FDA Link
11/2019 - 03/2007
10Infliximab (Remicade)FDA Link
07/2022 - 01/2007
10ametantrone (HAQ)IBA
02/2022 - 12/2005
10AntibodiesIBA
01/2018 - 06/2011
9Certolizumab PegolFDA Link
03/2020 - 07/2014
9AutoantibodiesIBA
01/2018 - 06/2011
9CytokinesIBA
08/2017 - 07/2008
8FebuxostatFDA Link
12/2021 - 06/2011
8HLA-DRB1 Chains (HLA DRB1)IBA
01/2018 - 12/2011
7DenosumabFDA Link
11/2021 - 06/2016
7Tacrolimus (Prograf)FDA LinkGeneric
01/2021 - 10/2010
7Prednisolone (Predate)FDA LinkGeneric
05/2020 - 06/2011
7Rheumatoid FactorIBA
11/2019 - 01/2007
6Abatacept (Orencia)FDA Link
08/2022 - 09/2014
6EpitopesIBA
11/2019 - 01/2012
6golimumabFDA Link
09/2018 - 06/2012
6Ferritins (Ferritin)IBA
01/2018 - 07/2010
6Interleukin-6 (Interleukin 6)IBA
01/2018 - 10/2009
5Allopurinol (Remid)FDA LinkGeneric
12/2021 - 06/2011
5Tumor Necrosis Factor InhibitorsIBA
07/2021 - 04/2012
5Anti-Citrullinated Protein AntibodiesIBA
03/2020 - 05/2011
5Sulfasalazine (Azulfidine)FDA LinkGeneric
01/2020 - 12/2002
5bucillamine (SA 96)IBA
01/2020 - 01/2005
5tofacitinibIBA
09/2019 - 10/2014
5Biomarkers (Surrogate Marker)IBA
07/2019 - 01/2009
5EnzymesIBA
11/2018 - 12/2002
5Peptides (Polypeptides)IBA
01/2018 - 01/2013
5Interleukin-17 (Interleukin 17)IBA
08/2017 - 10/2009
5DNA (Deoxyribonucleic Acid)IBA
03/2014 - 01/2009
5Xanthine OxidaseIBA
06/2011 - 06/2011
5purineIBA
06/2011 - 03/2011
4Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
02/2022 - 01/2005
4C-Reactive ProteinIBA
01/2021 - 01/2007
4SteroidsIBA
01/2020 - 05/2007
4Amino AcidsFDA Link
08/2016 - 10/2013
4Interleukin-18 (Interleukin 18)IBA
04/2014 - 10/2010
4Therapeutic UsesIBA
08/2012 - 01/2005
3Biosimilar PharmaceuticalsIBA
07/2022 - 03/2020
3CT-P13IBA
07/2022 - 01/2015
3InterleukinsIBA
07/2021 - 01/2016
3hydroxide ionIBA
01/2021 - 07/2013
3Leflunomide (Arava)FDA LinkGeneric
01/2020 - 06/2003
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2020 - 06/2011
3sirukumabIBA
03/2019 - 01/2018
3HLA Antigens (Human Leukocyte Antigens)IBA
10/2018 - 01/2014
3Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA
12/2014 - 09/2012
3cyclic citrullinated peptideIBA
08/2014 - 05/2011
3Nucleic AcidsIBA
07/2012 - 04/2008
3Matrix Metalloproteinases (MMPs)IBA
01/2010 - 01/2005
2Chemokine CX3CL1IBA
07/2021 - 01/2021
2quetmolimabIBA
07/2021 - 01/2021
2olokizumabIBA
07/2021 - 01/2016
2Immunoglobulin G (IgG)IBA
01/2021 - 05/2011
2amsonic acid (DAS)IBA
09/2020 - 01/2017
2Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2020 - 01/2018
2LigandsIBA
01/2020 - 10/2009

Therapy/Procedure

42Therapeutics
12/2021 - 06/2004
3Knee Replacement Arthroplasty (Total Knee Replacement)
10/2010 - 01/2007
2Drug Therapy (Chemotherapy)
10/2020 - 01/2003
2Drug Tapering
05/2020 - 01/2020